LOXL1
Sign in to saveAlso known as LOL, LOXL, lysyl oxidase like 1
Lysyl oxidase homolog 1, also known as LOXL1, is an enzyme which in humans is encoded by the LOXL1 gene.
Gene data
LOXL1- Name
- lysyl oxidase like 1
- Type
- protein-coding
- Aliases
- LOL, LOXL
This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome. [provided by RefSeq, Jan 2016].
via MyGene.info
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
Lysyl oxidase homolog 1, also known as LOXL1, is an enzyme which in humans is encoded by the LOXL1 gene.
== Function ==
Excerpted from Wikipedia’s “LOXL1” article, available under the CC BY-SA 4.0 licence.