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GeneQ6459672· pop 5· linked from 4 articles

LPCAT1

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Also known as lysophosphatidylcholine acyltransferase 1, AYTL2, PFAAP3, lpcat, AGPAT10, AGPAT9, LPCAT-1, lysoPAFAT

Lysophosphatidylcholine acyltransferase 1 is a protein in humans that is encoded by the LPCAT1 gene.

Gene data

LPCAT1
Name
lysophosphatidylcholine acyltransferase 1
Type
protein-coding
Position
1,456,480–1,524,282 (−)
Aliases
AGPAT10, AGPAT9, AYTL2, LPCAT-1, LPLAT8, PFAAP3, lpcat, lysoPAFAT
Ensembl
ENSG00000153395
RefSeq RNA
NM_024830.5, XM_005248373.4, XM_011514132.2, XM_011514134.2, XM_047417763.1
RefSeq protein
NP_079106.3, XP_005248430.1, XP_011512434.2, XP_011512436.1, XP_047273719.1

This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016].

Gene Ontology

Pathways

Glycerophospholipid metabolism - Homo sapiens (human)Ether lipid metabolism - Homo sapiens (human)MetabolismAcyl chain remodelling of PCAcyl chain remodelling of PGSynthesis of PASynthesis of PCGlycerophospholipid biosynthesisPhospholipid metabolismInnate Immune System

via MyGene.info

Gene · Ensembl

lysophosphatidylcholine acyltransferase 1

Symbol
LPCAT1
Biotype
Protein coding
Organism
Homo sapiens
Location
Chr HSCHR5_3_CTG1:8,170-53,293
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
9871
genomic start
1456595
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/79888
chromosome
human chromosome 5
genomic end
1523962
cytogenetic location
5p15.33
expressed in
appendix
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

1 sections
Contents
  • References

Lysophosphatidylcholine acyltransferase 1 is a protein in humans that is encoded by the LPCAT1 gene.

Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis.

Excerpted from Wikipedia’s “LPCAT1” article, available under the CC BY-SA 4.0 licence.

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