LPIN1
Sign in to saveAlso known as PAP1, lipin 1
Lipin-1 is a protein that in humans is encoded by the LPIN1 gene.
Gene data
LPIN1- Name
- lipin 1
- Type
- protein-coding
- Aliases
- PAP1
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017].
via MyGene.info
Gene · Ensembl
lipin 1
- Symbol
- LPIN1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:11,677,539-11,828,185
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 9266
- exact match
- identifiers.org/ncbigene/23175
- genomic start
- 11817721
- genomic end
- 11967535
- cytogenetic location
- 2p25.1
Sources (7)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Lipin-1 is a protein that in humans is encoded by the LPIN1 gene.
== Function ==