LRRTM1
Sign in to saveAlso known as entrez:347730, leucine rich repeat transmembrane neuronal 1
LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons. As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).
Gene data
LRRTM1- Name
- leucine rich repeat transmembrane neuronal 1
- Type
- protein-coding
- Position
- 80,288,351–80,304,757 (−)
- Ensembl
- ENSG00000162951
- RefSeq RNA
- NM_178839.5, XM_017003986.3, XM_017003987.3, XM_047444146.1, XM_054341768.1
- RefSeq protein
- NP_849161.2, XP_016859475.1, XP_016859476.1, XP_047300102.1, XP_054197743.1
Predicted to be involved in regulation of postsynaptic density assembly and regulation of presynapse assembly. Predicted to act upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Located in endoplasmic reticulum and growth cone. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Molecular function
via MyGene.info
Gene · Ensembl
leucine rich repeat transmembrane neuronal 1
- Symbol
- LRRTM1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:80,288,351-80,304,757
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 41763
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/347730
- chromosome
- human chromosome 2
- genomic start
- 80515483
- genomic end
- 80304752
- cytogenetic location
- 2p12
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Clinical significance
- See also
- References
- Further reading
LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons. As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).
== Clinical significance ==
Excerpted from Wikipedia’s “LRRTM1” article, available under the CC BY-SA 4.0 licence.