LRRTM1
Sign in to saveAlso known as entrez:347730, leucine rich repeat transmembrane neuronal 1
LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons. As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).
Gene data
LRRTM1- Name
- leucine rich repeat transmembrane neuronal 1
- Type
- protein-coding
Predicted to be involved in regulation of postsynaptic density assembly and regulation of presynapse assembly. Predicted to act upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Located in endoplasmic reticulum and growth cone. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 41763
- exact match
- identifiers.org/ncbigene/347730
- genomic start
- 80515483
- genomic end
- 80304752
- cytogenetic location
- 2p12
Sources (3)
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Article
4 sectionsContents
- Clinical significance
- See also
- References
- Further reading
LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons. As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).
== Clinical significance ==