LZTFL1

Also known as BBS17, leucine zipper transcription factor like 1

Leucine zipper transcription factor like 1 also known as LZTFL1 is a ubiquitously expressed protein which localizes to the cytoplasm and in humans is encoded by the LZTFL1 gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to LZTFL1, and connects out to PubMed, Ensembl genome database project and COVID-19.

Vinony files it under Genes on human chromosome 3, Human genetics and Proteins.

Vinony links it to 6 Wikipedia language editions.

Gene data

LZTFL1

Name: leucine zipper transcription factor like 1
Type: protein-coding
Position: 45,823,316–45,916,042 (−)
Aliases: BBS17
Ensembl: ENSG00000163818
RefSeq RNA: NM_001276378.2, NM_001276379.2, NM_001386451.1, NM_001386452.1, NM_001405920.1
RefSeq protein: NP_001263307.1, NP_001263308.1, NP_001373380.1, NP_001373381.1, NP_001392849.1

This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. [provided by RefSeq, Aug 2020].

Gene Ontology

Biological process

flagellated sperm motility negative regulation of protein localization to cilium negative regulation of protein localization to cilium negative regulation of protein localization to ciliary membrane

Molecular function

protein binding identical protein binding protein-containing complex binding protein-containing complex binding

Cellular component

manchette cytoplasm cytoplasm cytosol cytosol cilium cilium

Pathways

Organelle biogenesis and maintenance Cilium Assembly Cargo trafficking to the periciliary membrane BBSome-mediated cargo-targeting to cilium Assembly of the 9+0 primary cilium Ciliary landscape Genes related to primary cilium development (based on CRISPR)Ciliopathies

via MyGene.info

Gene · Ensembl

leucine zipper transcription factor like 1

Symbol: LZTFL1
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:45,823,316-45,916,042
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 41368
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/54585
genomic end: 45957534
genomic start: 45864808
chromosome: human chromosome 3
cytogenetic location: 3p21.31

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

Function
Clinical significance
References

Leucine zipper transcription factor like 1 also known as LZTFL1 is a ubiquitously expressed protein which localizes to the cytoplasm and in humans is encoded by the LZTFL1 gene.

== Function == This protein regulates protein trafficking to the ciliary membrane through interaction with the Bardet-Biedl syndrome (BBS) complex of proteins.

Excerpted from Wikipedia’s “LZTFL1” article, available under the CC BY-SA 4.0 licence.