mafosfamide
Sign in to saveMafosfamide (INN; development code ASTA-Z-7557) is an oxazaphosphorine (cyclophosphamide-like) alkylating agent under investigation as a chemotherapeutic. It is metabolized by cytochrome P450 into 4-hydroxycyclophosphamide, which is then converted into aldophosphamide, which, in turn yields the cytotoxic metabolites phosphoramide mustard and acrolein.
Chemical data
- Formula
- C9H19Cl2N2O5PS2
- Molecular weight
- 401.3 g/mol
- IUPAC name
- 2-[[(2S,4S)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-4-yl]sulfanyl]ethanesulfonic acid
via PubChem
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- carbon
- Mass
- +399.985
Show 2 more facts
- P2868
- immunologic adjuvant
- P366
- medication
via Wikidata · CC0
Article
2 sectionsContents
- References
- Further reading
{{chembox | Verifiedfields = changed | verifiedrevid = 477499263 | ImageFile = Mafosfamide.svg | ImageClass = skin-invert-image | ImageSize = 175 | ImageAlt = Skeletal formula | ImageFile1 = Mafosfamide-3D-balls.png | ImageClass1 = bg-transparent | ImageSize1 = 230 | ImageAlt1 = Ball-and-stick model | IUPACName=2-{(2-[bis(2-chloroethyl)amino]-2-oxido-1,3,2-oxazaphosphinan-4-yl}thio)ethanesulfonic acid | OtherNames=2-{[2-[bis(2-chloroethyl)amino]-2-oxo-1-oxa-3-aza-2λ5-phosphacyclohex-4-yl}sulfanyl]ethanesulfonic acid ASTA-Z-7557
| Section1 =