MALAT1
Sign in to saveAlso known as HCN, LINC00047, MALAT-1, NCRNA00047, NEAT2, PRO2853, mascRNA, metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) also known as NEAT2 (Nuclear-Enriched Abundant Transcript 2) is an infrequently spliced long non-coding RNA, which is highly conserved amongst mammals and highly expressed in the nucleus. It regulates the expression of metastasis-associated genes. It also positively regulates cell motility via the transcriptional and/or post-transcriptional regulation of motility-related genes. MALAT1 may play a role in temperature-dependent sex determination in the Red-eared slider turtle (Trachemys scripta).
Research
3,043 papers- MALAT1-related signaling pathways in colorectal cancer.Cancer cell international · 2022
- MALAT1 Long Non-Coding RNA: Functional Implications.Non-coding RNA · 2020
- Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment.Science immunology · 2024
- The MALAT1-breast cancer interplay: insights and implications.Expert review of molecular diagnostics · 2023
- LncRNA MALAT1 promotes osteoarthritis by modulating miR-150-5p/AKT3 axis.Cell & bioscience · 2019
via PubMed
Wikidata facts
Show 4 more facts
- exact match
- identifiers.org/ncbigene/378938
- cytogenetic location
- 11q13.1
- genomic start
- 65265233
- genomic end
- 65273940
via Wikidata · CC0
~1 min read
Article
6 sectionsContents
- Expression in alcoholic brains
- Prognostic potential in cancer
- See also
- References
- Further reading
- External links
MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) also known as NEAT2 (Nuclear-Enriched Abundant Transcript 2) is an infrequently spliced long non-coding RNA, which is highly conserved amongst mammals and highly expressed in the nucleus. It regulates the expression of metastasis-associated genes. It also positively regulates cell motility via the transcriptional and/or post-transcriptional regulation of motility-related genes. MALAT1 may play a role in temperature-dependent sex determination in the Red-eared slider turtle (Trachemys scripta).
==Expression in alcoholic brains== Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans.