MANF
Sign in to saveAlso known as ARMET, ARP, arginine-rich, mutated in early-stage tumors, arginine-rich protein, mesencephalic astrocyte-derived neurotrophic factor, mesencephalic astrocyte derived neurotrophic factor
gene umano
Gene data
MANF- Name
- mesencephalic astrocyte derived neurotrophic factor
- Type
- protein-coding
- Position
- 51,385,255–51,389,802 (+)
- Aliases
- ARMET, ARP, DDDS
- Ensembl
- ENSG00000145050
- RefSeq RNA
- NM_006010.6
- RefSeq protein
- NP_006001.5
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
mesencephalic astrocyte derived neurotrophic factor
- Symbol
- MANF
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:51,385,255-51,389,802
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MANF PDB 2KVD.png
Show 8 more facts
- HomoloGene ID
- 4383
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7873
- chromosome
- human chromosome 3
- genomic start
- 51385291
- genomic end
- 51426828
- cytogenetic location
- 3p21.2
- expressed in
- pericardium
Sources (4)
via Wikidata · CC0