Structure via PubChem · Public domain (PubChem)
maraviroc
Sign in to saveAlso known as UK 427857, UK-427,857
Maraviroc, sold under the brand names Selzentry (US) and Celsentri (EU), is an antiretroviral medication used to treat HIV infection. It is taken by mouth. It is in the CCR5 receptor antagonist class.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 477499940
- Drug.image
- Maraviroc.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 275
- Drug.alt
- Structural formula of maraviroc
- Drug.image2
- Maraviroc molecule ball.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250
- Drug.alt2
- Ball-and-stick model of the maraviroc molecule
- Drug.pronounce
- Selzentry:
- Drug.tradename
- Selzentry, Celsentri
- Drug.DailyMedID
- Maraviroc
- Drug.MedlinePlus
- a607076
- Drug.pregnancy_AU
- B1
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- J05
via Wikipedia infobox
Chemical data
- Formula
- C29H41F2N5O
- Molecular weight
- 513.7 g/mol
- IUPAC name
- 4,4-difluoro-N-[(1S)-3-[(1S,5R)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
- SMILES
- CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
- InChIKey
- GSNHKUDZZFZSJB-HLMSNRGBSA-N
- XLogP
- 5.1
- Polar surface area
- 63.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
1,423 papers- Maraviroc.Drugs of today (Barcelona, Spain : 1998) · 2007
- Maraviroc.Drugs · 2007
- Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.Nature communications · 2025
- Maraviroc: a new CCR5 antagonist.Expert review of anti-infective therapy · 2009
- Off-label use of maraviroc in clinical practice.Expert review of anti-infective therapy · 2016
via PubMed
Wikidata facts
- Mass
- 513.327917
- Has use
- medication
Show 10 more facts
- legal status (medicine)
- boxed warning
- chemical formula
- C₂₉H₄₁F₂N₅O
- subject has role
- bactericide
- World Health Organisation international non-proprietary name
- maraviroc
- medical condition treated
- graft-versus-host disease
- isomeric SMILES
- CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
- canonical SMILES
- CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
- defined daily dose
- 0.6
- physically interacts with
- C-C motif chemokine receptor 5
- Commons category
- Maraviroc
Sources (6)
via Wikidata · CC0
~6 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Side effects
- Mechanism of action
- History
- Names
- Research
- References
- Further reading
- External links
{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477499940 | image = Maraviroc.svg | image_class = skin-invert-image | width = 275 | alt = Structural formula of maraviroc | image2 = Maraviroc molecule ball.png | image_class2 = bg-transparent | width2 = 250 | alt2 = Ball-and-stick model of the maraviroc molecule
| pronounce = Selzentry: | tradename = Selzentry, Celsentri | Drugs.com = | DailyMedID = Maraviroc | MedlinePlus = a607076 | pregnancy_AU = B1 | pregnancy_category = | routes_of_administration = By mouth | ATC_prefix = J05 | ATC_suffix = AX09
Excerpted from Wikipedia’s “maraviroc” article, available under the CC BY-SA 4.0 licence.