MCM10

Name

minichromosome maintenance 10 replication initiation factor

Type

protein-coding

Position

13,161,526–13,211,110 (+)

Aliases

CNA43, DNA43, IMD80, PRO2249

Ensembl

ENSG00000065328

RefSeq RNA

NM_018518.5, NM_182751.3, XM_011519538.3, XM_047425437.1, XM_054366234.1

RefSeq protein

NP_060988.3, NP_877428.1, XP_011517840.1, XP_047281393.1, XP_054222209.1

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

minichromosome maintenance 10 replication initiation factor

Symbol

MCM10

Biotype

Protein coding

Organism

Homo sapiens

Location

10:13,161,526-13,211,110

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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