Gene data
MDFI- Name
- MyoD family inhibitor
- Type
- protein-coding
- Position
- 41,636,840–41,654,250 (+)
- Aliases
- I-MF, I-mfa
- Ensembl
- ENSG00000112559
- RefSeq RNA
- NM_001300804.2, NM_001300805.2, NM_001300806.2, NM_005586.4, XM_005249117.4
- RefSeq protein
- NP_001287733.1, NP_001287734.1, NP_001287735.1, NP_005577.1, XP_005249174.1
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IIdorsal/ventral axis specificationregulation of gene expressionregulation of Wnt signaling pathwaynegative regulation of Wnt signaling pathwaymaintenance of protein location in cellnegative regulation of DNA-templated transcriptionregulation of JNK cascade
Molecular function
via MyGene.info
Gene · Ensembl
MyoD family inhibitor
- Symbol
- MDFI
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:41,636,840-41,654,250
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 21150
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4188
- genomic end
- 41654244
- genomic start
- 41604620
- chromosome
- human chromosome 6
- cytogenetic location
- 6p21.1
- expressed in
- vagina
Sources (3)
via Wikidata · CC0