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GeneQ18039576· pop 6· linked from 3 articles

MED4

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Also known as ARC36, DRIP36, HSPC126, TRAP36, VDRIP, mediator complex subunit 4

Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.

Gene data

MED4

Name: mediator complex subunit 4
Type: protein-coding
Position: 48,001,823–48,095,150 (−)
Aliases: ARC36, DRIP36, HSPC126, TRAP36, VDRIP
Ensembl: ENSG00000136146
RefSeq RNA: NM_001270629.2, NM_014166.4
RefSeq protein: NP_001257558.1, NP_054885.1

This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II positive regulation of DNA-templated transcription RNA polymerase II preinitiation complex assembly positive regulation of transcription initiation by RNA polymerase II positive regulation of transcription initiation by RNA polymerase II

Molecular function

transcription coregulator activity transcription coregulator activity transcription coregulator activity transcription coactivator activity transcription coactivator activity protein binding nuclear vitamin D receptor binding nuclear thyroid hormone receptor binding

Cellular component

nucleus nucleus nucleoplasm nucleoplasm membrane mediator complex mediator complex core mediator complex

Pathways

Thyroid hormone signaling pathway - Homo sapiens (human)Developmental Biology Developmental Biology Metabolism Disease PPARA activates gene expression Epigenetic regulation of gene expression Epigenetic regulation of gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation

via MyGene.info

Gene · Ensembl

mediator complex subunit 4

Symbol: MED4
Biotype: Protein coding
Organism: Homo sapiens
Location: 13:48,001,823-48,095,150
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: The IDRc bound human core Mediator complex - Mediator of RNA polymerase II transcription subunit 4 (2) 8TRH.png

Show 7 more facts

HomoloGene ID: 8568
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/29079
genomic end: 48669267
genomic start: 48627459
chromosome: human chromosome 13
cytogenetic location: 13q14.2

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.

== Function ==

Excerpted from Wikipedia’s “MED4” article, available under the CC BY-SA 4.0 licence.

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