MLANA
Sign in to saveAlso known as MART-1, MART1, melan-A
thumb|Immunohistochemistry stain for Melan-A in a poorly differentiated metastatic melanoma to a lymph node, helping in its diagnosis Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA or "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.
Gene data
MLANA- Name
- melan-A
- Type
- protein-coding
- Position
- 5,890,873–5,910,606 (+)
- Aliases
- MART-1, MART1
- Ensembl
- ENSG00000120215
- RefSeq RNA
- NM_005511.2
- RefSeq protein
- NP_005502.1
Located in endoplasmic reticulum membrane; melanosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
melan-A
- Symbol
- MLANA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:5,890,873-5,910,606
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- PDB 2GUO - MHC HLA-A2 in complex with Melan-A-MART-1 27-35 peptide.png
Show 9 more facts
- HomoloGene ID
- 4026
- genomic start
- 5890889
- genetic association
- multiple sclerosis
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2315
- genomic end
- 5910606
- chromosome
- human chromosome 9
- cytogenetic location
- 9p24.1
- expressed in
- monocyte
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Discovery and nomenclature
- Clinical significance
- Structure
- Regulation
- References
- Further reading
thumb|Immunohistochemistry stain for Melan-A in a poorly differentiated metastatic melanoma to a lymph node, helping in its diagnosis Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA or "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.
== Discovery and nomenclature ==
Excerpted from Wikipedia’s “MLANA” article, available under the CC BY-SA 4.0 licence.