MTCH2

Also known as MIMP, SLC25A50, HSPC032, mitochondrial carrier 2

Genen från arten Homo sapiens

Gene data

MTCH2

Name: mitochondrial carrier 2
Type: protein-coding
Position: 47,604,339–47,642,698 (−)
Aliases: HSPC032, MIMP, SLC25A50
Ensembl: ENSG00000285121
RefSeq RNA: NM_001317231.2, NM_001317232.2, NM_001317233.2, NM_014342.4, XM_006718172.3
RefSeq protein: NP_001304160.1, NP_001304161.1, NP_001304162.1, NP_055157.1, XP_006718235.1

This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017].