MTRF1L

Also known as HMRF1L, MRF1L, mtRF1a, mitochondrial translational release factor 1 like, mitochondrial translation release factor 1 like, Mitochondrial translational release factor 1-like

Mitochondrial translational release factor 1-like is a protein that in humans is encoded by the MTRF1L gene.

Gene data

MTRF1L

Name: mitochondrial translation release factor 1 like
Type: protein-coding
Position: 152,987,362–153,002,709 (−)
Aliases: HMRF1L, MRF1L, mtRF1a
Ensembl: ENSG00000112031
RefSeq RNA: NM_001114184.3, NM_001301047.3, NM_001301870.2, NM_001301871.2, NM_001301872.2
RefSeq protein: NP_001107656.1, NP_001287976.1, NP_001288799.1, NP_001288800.1, NP_001288801.1

The protein encoded by this gene plays a role in mitochondrial translation termination, and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons, but has no in vitro activity against UGA, which encodes tryptophan in human mitochondrion, or, the mitochondrial non-cognate stop codons, AGA and AGG. This protein shares sequence similarity to bacterial release factors. Pseudogenes of this gene are found on chromosomes 4, 8, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].

Gene Ontology

Biological process

translational termination mitochondrial translational termination mitochondrial translational termination mitochondrial translational termination

Molecular function

translation release factor activity translation release factor activity translation release factor activity, codon specific translation release factor activity, codon specific

Cellular component

mitochondrion mitochondrion mitochondrion mitochondrion mitochondrion mitochondrial matrix mitochondrial matrix mitochondrial matrix

Pathways

Metabolism of proteins Mitochondrial translation Mitochondrial translation termination Translation

via MyGene.info

Gene · Ensembl

mitochondrial translation release factor 1 like

Symbol: MTRF1L
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:152,987,362-153,002,802
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 5905
exact match: identifiers.org/ncbigene/54516
genomic end: 153002709
genomic start: 153308497
cytogenetic location: 6q25.2

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Mitochondrial translational release factor 1-like is a protein that in humans is encoded by the MTRF1L gene.

Mitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain, while all proteins involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm. MTRF1L is a nuclear-encoded protein that functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein (summary by Nozaki et al., 2008 [PubMed 18429816]).[supplied by OMIM].