MUL1
Sign in to saveAlso known as C1orf166, GIDE, MAPL, MULAN, RNF218, mitochondrial E3 ubiquitin protein ligase 1
Mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1. This enzyme localizes to the outer mitochondrial membrane, where it regulates mitochondrial morphology and apoptosis through multiple pathways, including the Akt, JNK, and NF-κB. Its proapoptotic function thus implicates it in cancer and Parkinson's disease.
Gene data
MUL1- Name
- mitochondrial E3 ubiquitin protein ligase 1
- Type
- protein-coding
- Aliases
- C1orf166, GIDE, MAPL, MULAN, RNF218
Enables several functions, including p53 binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including negative regulation of defense response; positive regulation of cellular protein metabolic process; and regulation of mitochondrion organization. Located in several cellular components, including mitochondrion; neuronal cell body; and peroxisome. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 11576
- exact match
- identifiers.org/ncbigene/79594
- genomic start
- 20825943
- genomic end
- 20508151
- cytogenetic location
- 1p36.12
Sources (4)
via Wikidata · CC0
~6 min read
Article
7 sectionsContents
- Structure
- Gene
- Protein
- Function
- Clinical significance
- Interactions
- References
Mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1. This enzyme localizes to the outer mitochondrial membrane, where it regulates mitochondrial morphology and apoptosis through multiple pathways, including the Akt, JNK, and NF-κB. Its proapoptotic function thus implicates it in cancer and Parkinson's disease.
==Structure==