MUL1
Sign in to saveAlso known as C1orf166, GIDE, MAPL, MULAN, RNF218, mitochondrial E3 ubiquitin protein ligase 1
Mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1. This enzyme localizes to the outer mitochondrial membrane, where it regulates mitochondrial morphology and apoptosis through multiple pathways, including the Akt, JNK, and NF-κB. Its proapoptotic function thus implicates it in cancer and Parkinson's disease.
Gene data
MUL1- Name
- mitochondrial E3 ubiquitin protein ligase 1
- Type
- protein-coding
- Position
- 20,495,722–20,508,163 (−)
- Aliases
- C1orf166, GIDE, MAPL, MULAN, RNF218
- Ensembl
- ENSG00000090432
- RefSeq RNA
- NM_024544.3, XM_011542137.3, XM_054338734.1
- RefSeq protein
- NP_078820.2, XP_011540439.1, XP_054194709.1
Enables several functions, including p53 binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including negative regulation of defense response; positive regulation of cellular protein metabolic process; and regulation of mitochondrion organization. Located in several cellular components, including mitochondrion; neuronal cell body; and peroxisome. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
mitochondrial E3 ubiquitin protein ligase 1
- Symbol
- MUL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:20,495,722-20,508,163
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 11576
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/79594
- chromosome
- human chromosome 1
- genomic start
- 20825943
- genomic end
- 20508151
- cytogenetic location
- 1p36.12
Sources (4)
via Wikidata · CC0
~6 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Gene
- Protein
- Function
- Clinical significance
- Interactions
- References
Mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1. This enzyme localizes to the outer mitochondrial membrane, where it regulates mitochondrial morphology and apoptosis through multiple pathways, including the Akt, JNK, and NF-κB. Its proapoptotic function thus implicates it in cancer and Parkinson's disease.
==Structure==
Excerpted from Wikipedia’s “MUL1” article, available under the CC BY-SA 4.0 licence.