multiple organ dysfunction syndrome
Sign in to saveAlso known as MODS, multiple organ failure, MOF, multisystem organ failure, MSOF, multi-system organ failure, multi system organ failure, MOF ; multiple organ failure
altered organ function in an acutely ill patient requiring medical intervention to achieve homeostasis.
Key facts
- Other names
- Total organ failure, multisystem organ failure, multiple organ failure
- Specialty
- Intensive care medicine
- Symptoms
- Include, but not limited to: confusion, loss of appetite, fatigue, fever, irregular heartbeat, tachypnea
- Causes
- Infection, injury, hypermetabolism
- Treatment
- Treating the underlying cause
- Prognosis
- Case fatality rate 30–100% depending on the number of organs that fail
via Wikipedia infobox
Research
28,226 papers- Endothelial dysfunction: Pathophysiology and therapeutic targets for sepsis-induced multiple organ dysfunction syndrome.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
- Multiple Organ Dysfunction Syndrome.Journal of intensive care medicine · 2020
- Cytokine Storm and Sepsis-Induced Multiple Organ Dysfunction Syndrome.Advances in experimental medicine and biology · 2024
- Multiple Organ Dysfunction: The Defining Syndrome of Sepsis.Surgical infections · 2018
- Multiple organ dysfunction syndrome.The Yale journal of biology and medicine · 1993
via PubMed
~11 min read
Encyclopedic overview
Multiple organ dysfunction syndrome (MODS) is altered organ function in an acutely ill patient requiring immediate medical intervention.
There are different stages of organ dysfunction for certain different organs, both in acute and in chronic onset, whether or not there are one or more organs affected. Each stage of dysfunction (whether it be the heart, lung, liver, or kidney) has defined parameters, in terms of laboratory values based on blood and other tests, as to what it is (each of these organs' levels of failure is divided into stage I, II, III, IV, and V). The word "failure" is commonly used to refer to the later stages, especially IV and V, when artificial support usually becomes necessary to sustain life; the damage may or may not be fully or partially reversible.
Excerpted from Wikipedia’s “multiple organ dysfunction syndrome” article, available under the CC BY-SA 4.0 licence.