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N-methoxymethylamine
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'''N,O-Dimethylhydroxylamine''' is a methylated hydroxylamine used to form so called 'Weinreb amides' for use in the Weinreb ketone synthesis. It is commercially available as its hydrochloride salt.
In the Vinony graph
Vinony's link graph records 3 inbound references to N-methoxymethylamine, and connects out to methylation, hydrochloride and International Standard Book Number.
Vinony files it under Chembox having GHS data, Chembox image size set and Chemical articles with multiple CAS registry numbers.
Vinony links it to 9 Wikipedia language editions.
Chemical data
- Formula
- C2H7NO
- Molecular weight
- 61.08 g/mol
- IUPAC name
- N-methoxymethanamine
- SMILES
- CNOC
- InChIKey
- KRKPYFLIYNGWTE-UHFFFAOYSA-N
- XLogP
- -0.2
- Polar surface area
- 21.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 61.053
Show 4 more facts
- canonical SMILES
- CNOC
- chemical formula
- C₂H₇NO
- pKa
- 4.75
- Commons category
- N,O-Dimethylhydroxylamine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
'''N,O-Dimethylhydroxylamine''' is a methylated hydroxylamine used to form so called 'Weinreb amides' for use in the Weinreb ketone synthesis. It is commercially available as its hydrochloride salt.
==Synthesis== It may be prepared by reacting ethyl chloroformate (or similar) with hydroxylamine followed by treatment with a methylating agent such as dimethyl sulfate. The N,O-dimethylhydroxylamine is then liberated by acid hydrolysis followed by neutralization.
Excerpted from Wikipedia’s “N-methoxymethylamine” article, available under the CC BY-SA 4.0 licence.