NAA15
Sign in to saveAlso known as Ga19, NARG1, NAT1P, NATH, TBDN, TBDN100, N(alpha)-acetyltransferase 15, NatA auxiliary subunit, MRD50
N-alpha-acetyltransferase 15, NatA auxiliary subunit also known as gastric cancer antigen Ga19 (GA19), NMDA receptor-regulated protein 1 (NARG1), and Tbdn100 is a protein that in humans is encoded by the NAA15 gene. NARG1 is the auxiliary subunit of the NatA (Nα-acetyltransferase A) complex. This NatA complex can associate with the ribosome and catalyzes the transfer of an acetyl group to the Nα-terminal amino group of proteins as they emerge from the exit tunnel.
Gene data
NAA15- Name
- N-alpha-acetyltransferase 15, NatA auxiliary subunit
- Type
- protein-coding
- Aliases
- Ga19, MRD50, NARG1, NAT1P, NATH, TBDN, TBDN100
N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017].
via MyGene.info
Gene · Ensembl
N-alpha-acetyltransferase 15, NatA auxiliary subunit
- Symbol
- NAA15
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:139,301,446-139,420,033
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Naa15structure.png
Show 6 more facts
- HomoloGene ID
- 14211
- exact match
- identifiers.org/ncbigene/80155
- genomic end
- 140341187
- genomic start
- 139301505
- cytogenetic location
- 4q31.1
- Commons category
- N-alpha-acetyltransferase
via Wikidata · CC0
~5 min read
Article
7 sectionsContents
- Gene and transcripts
- Structure
- Function
- Disease
- Notes
- References
- Further reading
N-alpha-acetyltransferase 15, NatA auxiliary subunit also known as gastric cancer antigen Ga19 (GA19), NMDA receptor-regulated protein 1 (NARG1), and Tbdn100 is a protein that in humans is encoded by the NAA15 gene. NARG1 is the auxiliary subunit of the NatA (Nα-acetyltransferase A) complex. This NatA complex can associate with the ribosome and catalyzes the transfer of an acetyl group to the Nα-terminal amino group of proteins as they emerge from the exit tunnel.
== Gene and transcripts == Human NAA15 is located on chromosome 4q31.1 and contains 23 exons. Initially, 2 mRNA species were identified, of size 4.6 and 5.8 kb, both harboring the same open reading frame encoding a putative protein of 866 amino acids (~105 kDa) protein that can be detected in most human adult tissues. According to RefSeq/NCBI, only one human transcript variant exists, although 2 more isoforms are predicted. In addition to full length Naa15, an N-terminally truncated variant of Naa15 (named tubedown-1), Naa15273-865 has been described; however, in mouse only full length Naa15 is widely expressed, whereas smaller transcripts seem to visualized only in heart and testis.