Structure via PubChem · Public domain (PubChem)
Nardosinone
Sign in to saveNardosinone is a sesquiterpene and chemical constituent of Nardostachys jatamansi. In in vitro studies, the compound has demonstrated concentration-dependent enhancement of bucladesine and staurosporine-induced neurite outgrowth. Nardosinone has similarly been demonstrated to enhance NGF-mediated neurite outgrowth and synaptogenesis from PC12D cells.
Chemical data
- Formula
- C15H22O3
- Molecular weight
- 250.33 g/mol
- IUPAC name
- (3aR,9R,9aR,9bS)-1,1,9,9a-tetramethyl-3a,4,7,8,9,9b-hexahydronaphtho[2,1-c]dioxol-5-one
- SMILES
- C[C@@H]1CCC=C2[C@]1([C@H]3[C@@H](CC2=O)OOC3(C)C)C
- InChIKey
- KXGHHSIMRWPVQM-JWFUOXDNSA-N
- XLogP
- 2.9
- Polar surface area
- 35.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 250.156895
Show 4 more facts
- chemical formula
- C₁₅H₂₂O₃
- isomeric SMILES
- C[C@@H]1CCC=C2[C@]1([C@H]3[C@@H](CC2=O)OOC3(C)C)C
- canonical SMILES
- CC1CCC=C2C1(C3C(CC2=O)OOC3(C)C)C
- found in taxon
- Nardostachys jatamansi
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Nardosinone is a sesquiterpene and chemical constituent of Nardostachys jatamansi. In in vitro studies, the compound has demonstrated concentration-dependent enhancement of bucladesine and staurosporine-induced neurite outgrowth. Nardosinone has similarly been demonstrated to enhance NGF-mediated neurite outgrowth and synaptogenesis from PC12D cells.
Additionally, nardosinone has demonstrated cytotoxic activity against cultured P-388 lymphocytic leukemia cells.
Excerpted from Wikipedia’s “Nardosinone” article, available under the CC BY-SA 4.0 licence.