Structure via PubChem · Public domain (PubChem)
nepafenac
Sign in to saveAlso known as AHR-9434, AL-6515, Nevanac®, AHR 9434, 2-amino-3-benzoylbenzeneacetamide, AL 6515, Amfenac amide, Nepafenacum
Nepafenac, sold under the brand name Nevanac among others, is a nonsteroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop 0.1% solution (Nevanac) or 0.3% solution (Ilevro). It is used to treat pain and inflammation associated with cataract surgery. Nepafenac is a prodrug of amfenac, an inhibitor of COX-1 and COX-2 activity.
Chemical data
- Formula
- C15H14N2O2
- Molecular weight
- 254.28 g/mol
- IUPAC name
- 2-(2-amino-3-benzoylphenyl)acetamide
- SMILES
- C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N
- InChIKey
- QEFAQIPZVLVERP-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 86.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2005
- Admin. routes
- topical
- Indications
- eye inflammation, inflammation, Miosis, macular retinal edema
via ChEMBL · EBI
Research
288 papers- Nepafenac.2006
- Nepafenac in cataract surgery.Clinical & experimental optometry · 2022
- Nepafenac.Australian prescriber · 2017
- Nepafenac: an ophthalmic nonsteroidal antiinflammatory drug for pain after cataract surgery.The Annals of pharmacotherapy · 2013
- Nepafenac: a unique nonsteroidal prodrug.International ophthalmology clinics · 2006
via PubMed
Wikidata facts
- Subclass of
- non-steroidal anti-inflammatory drug
- Mass
- 254.106
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₅H₁₄N₂O₂
- canonical SMILES
- C1=CC=C(C=C1)C(=O)C2=C(C(=CC=C2)CC(=O)N)N
- World Health Organisation international non-proprietary name
- nepafenac
- subject has role
- non-steroidal anti-inflammatory drug
- Commons category
- Nepafenac
Sources (2)
via Wikidata · CC0
~7 min read
Encyclopedic overview
13 sectionsContents
- Medical uses
- Pharmacology
- Mechanism of action
- Adverse events
- Regulatory
- Nevanac
- Ilevro
- Commercialization
- Commercial risks
- Marketing
- Intellectual property
- References
- External links
Nepafenac, sold under the brand name Nevanac among others, is a nonsteroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop 0.1% solution (Nevanac) or 0.3% solution (Ilevro). It is used to treat pain and inflammation associated with cataract surgery. Nepafenac is a prodrug of amfenac, an inhibitor of COX-1 and COX-2 activity.
==Medical uses==
Excerpted from Wikipedia’s “nepafenac” article, available under the CC BY-SA 4.0 licence.