Nephrocystin 1
Sign in to saveAlso known as NPHP1, juvenile nephronophthisis 1 protein, nephronophthisis 1 (juvenile), nephrocystin-1
Nephrocystin-1 is a protein that in humans is encoded by the NPHP1 gene.
In the Vinony graph
Vinony's link graph records 63 inbound references to Nephrocystin 1, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 2.
Vinony links it to 7 Wikipedia language editions.
Protein · UniProt
Nephrocystin-1
- Gene
- NPHP1
- Organism
- Homo sapiens (Human)
- Length
- 732 aa
- Molecular mass
- 83,299 Da
- Evidence
- 1: Evidence at protein level
Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development (By similari…
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 3 more facts
- found in taxon
- Homo sapiens
- molecular function
- protein binding
- exact match
- purl.uniprot.org/uniprot/O15259
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Nephrocystin-1 is a protein that in humans is encoded by the NPHP1 gene.
== Function ==
Excerpted from Wikipedia’s “Nephrocystin 1” article, available under the CC BY-SA 4.0 licence.