Nephrocystin 1
Sign in to saveAlso known as NPHP1, juvenile nephronophthisis 1 protein, nephronophthisis 1 (juvenile), nephrocystin-1
Nephrocystin-1 is a protein that in humans is encoded by the NPHP1 gene.
Protein · UniProt
Nephrocystin-1
- Gene
- NPHP1
- Organism
- Homo sapiens (Human)
- Length
- 732 aa
- Molecular mass
- 83,299 Da
- Evidence
- 1: Evidence at protein level
Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development (By similari…
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 3 more facts
- found in taxon
- Homo sapiens
- molecular function
- protein binding
- exact match
- purl.uniprot.org/uniprot/O15259
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Nephrocystin-1 is a protein that in humans is encoded by the NPHP1 gene.
== Function ==
Excerpted from Wikipedia’s “Nephrocystin 1” article, available under the CC BY-SA 4.0 licence.