neurofibroma
Sign in to saveA neurofibroma is a benign nerve-sheath tumor in the peripheral nervous system. In 90% of cases, they are found as stand-alone tumors (solitary neurofibroma, solitary nerve sheath tumor or sporadic neurofibroma), while the remainder are found in persons with neurofibromatosis type I (NF1), an autosomal-dominant genetically inherited disease. They can result in a range of symptoms from physical disfiguration and pain to cognitive disability.
Key facts
- Medical condition (new).name
- Neurofibroma
- Medical condition (new).image
- Neurofibroma02.jpg
- Medical condition (new).caption
- Neurofibroma of the skin in a person with neurofibromatosis type I
- Medical condition (new).field
- Neuro-oncology
via Wikipedia infobox
Research
5,328,410 papers- Neurofibroma and schwannoma.Current opinion in neurology · 2002
- Solitary neurofibroma confined to inferior rectus muscle tendon: a case report.Orbit (Amsterdam, Netherlands) · 2025
- Tumors and tumor-like lesions of peripheral nerves.Seminars in musculoskeletal radiology · 2010
- [Melanotic neurofibroma].Annales de dermatologie et de venereologie · 2004
- Intraparotid plexiform neurofibroma: A rare diagnostic challenge.Diagnostic cytopathology · 2024
via PubMed
Wikidata facts
- Subclass of
- nerve sheath neoplasms
- Image
- Diffuse neurofibroma.jpg
Show 5 more facts
- Commons category
- Neurofibroma
- exact match
- purl.obolibrary.org/obo/DOID_962
- NCI Thesaurus ID
- C3272
- health specialty
- oncology
- on focus list of Wikimedia project
- WikiProject Medicine
Sources (2)
via Wikidata · CC0
~13 min read
Encyclopedic overview
25 sectionsContents
- Types
- Dermal neurofibroma
- Anatomy
- Age of onset
- Medical complications
- Plexiform neurofibroma
- Anatomy
- Age of onset
- Medical complications
- Cause
- Neurofibromin 1 gene
- Schwann cells
- Loss of tumor suppressor function
- Diagnosis
- Treatments
- Dermal neurofibroma
- Plexiform neurofibroma
- Surgery
- Radiation
- Medications
- No effect
- Research
- See also
- References
- External links
A neurofibroma is a benign nerve-sheath tumor in the peripheral nervous system. In 90% of cases, they are found as stand-alone tumors (solitary neurofibroma, solitary nerve sheath tumor or sporadic neurofibroma), while the remainder are found in persons with neurofibromatosis type I (NF1), an autosomal-dominant genetically inherited disease. They can result in a range of symptoms from physical disfiguration and pain to cognitive disability.
Neurofibromas arise from nonmyelinating-type Schwann cells that exhibit biallelic inactivation of the NF1 gene that codes for the protein neurofibromin. This protein is responsible for regulating the RAS-mediated cell growth signaling pathway. In contrast to schwannomas, another type of tumor arising from Schwann cells, neurofibromas incorporate many additional types of cells and structural elements in addition to Schwann cells, making it difficult to identify and understand all the mechanisms through which they originate and develop.
Excerpted from Wikipedia’s “neurofibroma” article, available under the CC BY-SA 4.0 licence.