neurofibroma
A neurofibroma is a benign nerve-sheath tumor in the peripheral nervous system. In 90% of cases, they are found as stand-alone tumors (solitary neurofibroma, solitary nerve sheath tumor or sporadic neurofibroma), while the remainder are found in persons with neurofibromatosis type I (NF1), an autosomal-dominant genetically inherited disease. They can result in a range of symptoms from physical disfiguration and pain to cognitive disability.
Key facts
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- Neurofibroma
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- Neurofibroma of the skin in a person with neurofibromatosis type I
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- Neuro-oncology
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Research
5,328,410 papers- Neurofibroma and schwannoma.Current opinion in neurology · 2002
- Solitary neurofibroma confined to inferior rectus muscle tendon: a case report.Orbit (Amsterdam, Netherlands) · 2025
- Tumors and tumor-like lesions of peripheral nerves.Seminars in musculoskeletal radiology · 2010
- [Melanotic neurofibroma].Annales de dermatologie et de venereologie · 2004
Article
25 sectionsContents
- Types
- Dermal neurofibroma
- Anatomy
- Age of onset
- Medical complications
- Plexiform neurofibroma
- Anatomy
- Age of onset
- Medical complications
- Cause
- Neurofibromin 1 gene
- Schwann cells
- Loss of tumor suppressor function
- Diagnosis
- Treatments
- Dermal neurofibroma
- Plexiform neurofibroma
- Surgery
- Radiation
- Medications
- No effect
- Research
- See also
- References
- External links
A neurofibroma is a benign nerve-sheath tumor in the peripheral nervous system. In 90% of cases, they are found as stand-alone tumors (solitary neurofibroma, solitary nerve sheath tumor or sporadic neurofibroma), while the remainder are found in persons with neurofibromatosis type I (NF1), an autosomal-dominant genetically inherited disease. They can result in a range of symptoms from physical disfiguration and pain to cognitive disability.
Neurofibromas arise from nonmyelinating-type Schwann cells that exhibit biallelic inactivation of the NF1 gene that codes for the protein neurofibromin. This protein is responsible for regulating the RAS-mediated cell growth signaling pathway. In contrast to schwannomas, another type of tumor arising from Schwann cells, neurofibromas incorporate many additional types of cells and structural elements in addition to Schwann cells, making it difficult to identify and understand all the mechanisms through which they originate and develop.