NFKBIZ
Sign in to saveAlso known as IKBZ, INAP, MAIL, NFKB inhibitor zeta
NF-kappa-B inhibitor zeta (IκBζ) is a protein that in humans is encoded by the NFKBIZ gene. This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-κB proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 pro
Gene data
NFKBIZ- Name
- NFKB inhibitor zeta
- Type
- protein-coding
- Position
- 101,827,991–101,861,022 (+)
- Aliases
- I-kappa-B-zeta, IKBZ, INAP, IkappaB-zeta, MAIL, ikB-zeta, ikappaBzeta
- Ensembl
- ENSG00000144802
- RefSeq RNA
- NM_001005474.3, NM_031419.4
- RefSeq protein
- NP_001005474.1, NP_113607.1
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
NFKB inhibitor zeta
- Symbol
- NFKBIZ
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:101,827,991-101,861,022
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 12734
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/64332
- genomic end
- 101579866
- genomic start
- 101546835
- chromosome
- human chromosome 3
- cytogenetic location
- 3q12.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Clinical relevance
- References
- Further reading
NF-kappa-B inhibitor zeta (IκBζ) is a protein that in humans is encoded by the NFKBIZ gene. This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-κB proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.
== Clinical relevance == NFKBIZ has been implicated as an oncogene in diffuse large B-cell lymphoma (DLBCL). Specifically, genomic locus containing this gene is recurrently amplified in copy number in the activated B-cell (ABC) subgroup of DLBCL. More recently, a recurrence of somatic mutations affecting the 3-prime untranslated region of NFKBIZ were found to promote NFKBIZ expression in ABC DLBCL.
Excerpted from Wikipedia’s “NFKBIZ” article, available under the CC BY-SA 4.0 licence.