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GeneQ18030132· pop 5· linked from 2 articles

NHLH1

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Also known as HEN1, NSCL, NSCL1, bHLHa35, nescient helix-loop-helix 1

Helix-loop-helix protein 1 is a protein that in humans is encoded by the NHLH1 gene.

Gene data

NHLH1

Name: nescient helix-loop-helix 1
Type: protein-coding
Position: 160,367,071–160,372,846 (+)
Aliases: HEN1, NSCL, NSCL1, bHLHa35
Ensembl: ENSG00000171786
RefSeq RNA: NM_005598.4
RefSeq protein: NP_005589.1

The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II central nervous system development central nervous system development positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific protein binding protein dimerization activity

Cellular component

chromatin nucleus nucleus

via MyGene.info

Gene · Ensembl

nescient helix-loop-helix 1

Symbol: NHLH1
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:160,367,071-160,372,846
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 4089
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4807
genomic end: 160372846
genomic start: 160367071
chromosome: human chromosome 1
cytogenetic location: 1q23.2

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Helix-loop-helix protein 1 is a protein that in humans is encoded by the NHLH1 gene.

The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM]

Excerpted from Wikipedia’s “NHLH1” article, available under the CC BY-SA 4.0 licence.

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