NKG7
Sign in to saveAlso known as GIG1, GMP-17, p15-TIA-1, natural killer cell granule protein 7
Natural killer cell granule protein 7 (NKG7 protein) is a protein that in humans is encoded by the NKG7 gene. The protein is under study regarding potential in cancer research into T cell activity. A role of the NKG7 protein in regulating cell resistance and fighting tumors in certain types of cancer is being studied because of its ability to recognize and kill cancer cells through CD8+ T cell resilience that is essential for anti-tumor activity. The research suggests that the NKG7 protein allows the CD8+ T cells to continue killing malignant cells in certain circumstances and may prevent gro
Gene data
NKG7- Name
- natural killer cell granule protein 7
- Type
- protein-coding
- Position
- 51,371,606–51,375,628 (−)
- Aliases
- GIG1, GMP-17, p15-TIA-1
- Ensembl
- ENSG00000105374
- RefSeq RNA
- NM_001363693.2, NM_005601.4, XM_005258955.4, XM_006723228.4, XM_054321078.1
- RefSeq protein
- NP_001350622.1, NP_005592.1, XP_005259012.1, XP_006723291.1, XP_054177053.1
Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
natural killer cell granule protein 7
- Symbol
- NKG7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:51,371,606-51,375,628
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Natural killer cell granule protein 7 (NKG7 protein) is a protein that in humans is encoded by the NKG7 gene. The protein is under study regarding potential in cancer research into T cell activity. A role of the NKG7 protein in regulating cell resistance and fighting tumors in certain types of cancer is being studied because of its ability to recognize and kill cancer cells through CD8+ T cell resilience that is essential for anti-tumor activity. The research suggests that the NKG7 protein allows the CD8+ T cells to continue killing malignant cells in certain circumstances and may prevent growth and metastasis of the malignant cells being attacked by the CD8+ T cells.
== References ==
Excerpted from Wikipedia’s “NKG7” article, available under the CC BY-SA 4.0 licence.