NNMT
Sign in to saveAlso known as nicotinamide N-methyltransferase
Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene. NNMT catalyzes the methylation of nicotinamide and similar compounds using the methyl donor S-adenosyl methionine (SAM-e) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide.
Gene data
NNMT- Name
- nicotinamide N-methyltransferase
- Type
- protein-coding
- Position
- 114,257,765–114,360,039 (+)
- Ensembl
- ENSG00000166741
- RefSeq RNA
- NM_001372045.1, NM_001372046.1, NM_001372047.1, NM_006169.3, NR_164073.1
- RefSeq protein
- NP_001358974.1, NP_001358975.1, NP_001358976.1, NP_006160.1
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
nicotinamide N-methyltransferase
- Symbol
- NNMT
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:114,257,765-114,360,039
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene. NNMT catalyzes the methylation of nicotinamide and similar compounds using the methyl donor S-adenosyl methionine (SAM-e) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide.
==Function== Methylation of nicotinamide by NNMT and SAM-e is the major pathway for degradation of nicotinamide leading to excretion in the urine.
Excerpted from Wikipedia’s “NNMT” article, available under the CC BY-SA 4.0 licence.