nociceptor
Sign in to saveAlso known as nociceptors, pain receptor cell, pain receptor, nocireceptor
A nociceptor () is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals to the spinal cord and the brain. The brain creates the sensation of pain to direct attention to the body part, so the threat can be mitigated; this process is called nociception.
Key facts
- Anatomy.Name
- Nociceptor
- Anatomy.Image
- Structure_of_sensory_system_(4_models)_E.PNG
- Anatomy.Caption
- Four types of sensory neurons and their receptor cells. Nociceptors shown as free nerve endings type A
via Wikipedia infobox
Research
15,455 papers- Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.Trends in immunology · 2017
- Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.Cell · 2022
- Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity.Cell · 2024
- Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8(+) T cell responses in vitiligo.Immunity · 2025
- Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells.Cell research · 2025
via PubMed
~14 min read
Encyclopedic overview
17 sectionsContents
- Terminology
- Scientific investigation
- Location
- Types and functions
- Thermal
- Mechanical
- Chemical
- Sleeping/silent
- Polymodal
- Pathway
- Ascending
- Descending
- Sensitivity
- Neural development
- In other animals
- See also
- References
A nociceptor () is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals to the spinal cord and the brain. The brain creates the sensation of pain to direct attention to the body part, so the threat can be mitigated; this process is called nociception.
==Terminology== Nociception and pain are usually evoked only by pressures and temperatures that are potentially damaging to tissues. This barrier or threshold contrasts with the more sensitive visual, auditory, olfactory, taste, and somatosensory responses to stimuli. The experience of pain is individualistic and can be suppressed by stress or exacerbated by anticipation. Simple activation of a nociceptor does not always lead to perceived pain, because the latter also depends on the frequency of the action potentials, integration of pre- and postsynaptic signals, and influences from higher or central processes.
Excerpted from Wikipedia’s “nociceptor” article, available under the CC BY-SA 4.0 licence.