nonactin
Sign in to saveNonactin is a member of a family of naturally occurring cyclic ionophores known as the macrotetrolide antibiotics. The other members of this homologous family are monactin, dinactin, trinactin and tetranactin which are all neutral ionophoric substances and higher homologs of nonactin. Collectively, this class is known as the nactins. Nonactin is soluble in acetone, dichloromethane, ethyl acetate and DMSO, but insoluble in water.
Wikidata facts
- Mass
- 736.44
Show 3 more facts
- canonical SMILES
- CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C
- chemical formula
- C₄₀H₆₄O₁₂
- isomeric SMILES
- C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C
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Article
7 sectionsContents
- Sources
- Structure and properties
- Reactions
- Biological effects
- Applications
- References
- Further reading
Nonactin is a member of a family of naturally occurring cyclic ionophores known as the macrotetrolide antibiotics. The other members of this homologous family are monactin, dinactin, trinactin and tetranactin which are all neutral ionophoric substances and higher homologs of nonactin. Collectively, this class is known as the nactins. Nonactin is soluble in acetone, dichloromethane, ethyl acetate and DMSO, but insoluble in water.
==Sources== Nonactin is commercially available; as of 2006, these bacterial species produce nonactin: Streptomyces tsukubensis, Streptomyces griseus, Streptomyces chrysomallus and Streptomyces werraensis. Total syntheses have been reported.