NOS1AP

Also known as 6330408P19Rik, CAPON, nitric oxide synthase 1 adaptor protein, NPHS22

Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein that in humans is encoded by the NOS1AP gene.

Gene data

NOS1AP

Name: nitric oxide synthase 1 adaptor protein
Type: protein-coding
Position: 162,069,676–162,370,475 (+)
Aliases: 6330408P19Rik, CAPON, NPHS22
Ensembl: ENSG00000198929
RefSeq RNA: NM_001126060.2, NM_001164757.2, NM_014697.3
RefSeq protein: NP_001119532.2, NP_001158229.1, NP_055512.1

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009].

Pathways

Circadian entrainment - Homo sapiens (human)Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

via MyGene.info

Gene · Ensembl

nitric oxide synthase 1 adaptor protein

Symbol: NOS1AP
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:162,069,676-162,370,475
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 136252
genetic association: obesity
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9722
genomic end: 162353321
genomic start: 162069691
chromosome: human chromosome 1
cytogenetic location: 1q23.3
expressed in: parietal lobe

Sources (5)

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Encyclopedic overview

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Contents

Interactions
References
Further reading

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. NOS1AP polymorphisms has been associated with the QT interval length.

Excerpted from Wikipedia’s “NOS1AP” article, available under the CC BY-SA 4.0 licence.