NOTCH2NLA
Sign in to saveAlso known as N2N, notch 2 N-terminal like, notch 2 N-terminal like A, NOTCH2NL
Notch homolog 2 N-terminal-like is a family of proteins that in humans consists of 3 proteins (NOTCH2NLA, NOTCH2NLB, and NOTCH2NLC) and is encoded by NOTCH2NL gene. It appears to play a key role in the development of the prefrontal cortex, a part of the brain.
Gene data
NOTCH2NLA- Name
- notch 2 N-terminal like A
- Type
- protein-coding
- Position
- 146,145,524–146,229,073 (−)
- Aliases
- N2N, NOTCH2NL
- Ensembl
- ENSG00000264343
- RefSeq RNA
- NM_001364006.2, NM_001395231.1, NM_001395232.1, NM_203458.6
- RefSeq protein
- NP_001350935.1, NP_001382160.1, NP_001382161.1, NP_982283.2
Enables Notch binding activity. Involved in cerebral cortex development and positive regulation of Notch signaling pathway. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
notch 2 N-terminal like A
- Symbol
- NOTCH2NLA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:146,145,524-146,229,073
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 89329
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/388677
- chromosome
- human chromosome 1
- genomic start
- 145209119
- genomic end
- 146229041
- cytogenetic location
- 1q21.1
Sources (3)
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Structure and function
- Human specificity
- Role in brain development
- Evolutionary implications
- Dysfunction and neurological disorders
- References
- External links
Notch homolog 2 N-terminal-like is a family of proteins that in humans consists of 3 proteins (NOTCH2NLA, NOTCH2NLB, and NOTCH2NLC) and is encoded by NOTCH2NL gene. It appears to play a key role in the development of the prefrontal cortex, a part of the brain.
NOTCH2NL increases the number of cortical stem cells, which while delaying the generation of neurons ultimately leads to a greater number of neurons and larger brains. NOTCH2NL copy number loss and gain is associated with various neurological disorders, and they showed that loss of NOTCH2NL in cortical organoids leads to the organoids being smaller, while resulting in premature differentiation of cortical stem cells into neurons. The role of NOTCH2NL in the development of the human brain together with the evolutionary history of NOTCH2NL genes, suggests that the emergence of NOTCH2NL genes may have contributed to the increase in size of the human neocortex which tripled over the last two million years.
Excerpted from Wikipedia’s “NOTCH2NLA” article, available under the CC BY-SA 4.0 licence.