NSUN2

Also known as MISU, MRT5, SAKI, TRM4, NOP2/Sun RNA methyltransferase family member 2, NOP2/Sun RNA methyltransferase 2

NOP2/Sun domain family, member 2 is a protein that in humans is encoded by the NSUN2 gene. Alternatively spliced transcript variants encoding different isoforms have been noted for the gene.

Gene data

NSUN2

Name: NOP2/Sun RNA methyltransferase 2
Type: protein-coding
Position: 6,599,237–6,633,304 (−)
Aliases: MISU, MRT5, SAKI, TRM4
Ensembl: ENSG00000037474
RefSeq RNA: NM_001193455.2, NM_017755.6, NR_037947.2, XM_054352868.1
RefSeq protein: NP_001180384.1, NP_060225.4, XP_054208843.1

This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011].

Pathways

tRNA modification in the nucleus and cytosol tRNA modification in the nucleus and cytosol tRNA processing tRNA processing Metabolism of RNA Metabolism of RNA

via MyGene.info

Wikidata facts

Show 5 more facts

HomoloGene ID: 9817
exact match: identifiers.org/ncbigene/54888
genomic end: 6633404
genomic start: 6599352
cytogenetic location: 5p15.31

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Article

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Contents

Function
Clinical relevance
References
Further reading

NOP2/Sun domain family, member 2 is a protein that in humans is encoded by the NSUN2 gene. Alternatively spliced transcript variants encoding different isoforms have been noted for the gene.

== Function ==