NUDT4
Sign in to saveAlso known as DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P, nudix hydrolase 4, DIPP-2B, NUDT4B
Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.
Gene data
NUDT4- Name
- nudix hydrolase 4
- Type
- protein-coding
- Position
- 93,377,883–93,410,297 (+)
- Aliases
- DIPP-2B, DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P
- Ensembl
- ENSG00000173598
- RefSeq RNA
- NM_001301022.2, NM_001301023.2, NM_001301024.2, NM_019094.6, NM_199040.4
- RefSeq protein
- NP_001287951.1, NP_001287952.1, NP_001287953.1, NP_061967.3, NP_950241.1
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
nudix hydrolase 4
- Symbol
- NUDT4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:93,377,883-93,410,297
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.
Excerpted from Wikipedia’s “NUDT4” article, available under the CC BY-SA 4.0 licence.