NUFIP1

Also known as NUFIP, bA540M5.1, NUFIP1, FMR1 interacting protein 1, nuclear FMR1 interacting protein 1, Rsa1

Nuclear fragile X mental retardation-interacting protein 1 is a protein that in humans is encoded by the NUFIP1 gene.

Gene data

NUFIP1

Name: nuclear FMR1 interacting protein 1
Type: protein-coding
Position: 44,937,964–44,989,493 (−)
Aliases: NUFIP, Rsa1, bA540M5.1
Ensembl: ENSG00000083635
RefSeq RNA: NM_012345.3, XR_008488755.1, XR_941559.3
RefSeq protein: NP_036477.2

This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. [provided by RefSeq, Feb 2012].