PALS2
Sign in to saveAlso known as VAM1, membrane palmitoylated protein 6, protein associated with LIN7 2, MAGUK family member, protein associated with LIN7 2, MAGUK p55 family member, MPP6, VAM-1, p55T
MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene.
Gene data
PALS2- Name
- protein associated with LIN7 2, MAGUK p55 family member
- Type
- protein-coding
- Position
- 24,572,936–24,694,193 (+)
- Aliases
- MPP6, VAM-1, VAM1, p55T
- Ensembl
- ENSG00000105926
- RefSeq RNA
- NM_001303037.2, NM_016447.4, XM_005249775.6, XM_006715738.4, XM_006715739.4
- RefSeq protein
- NP_001289966.1, NP_057531.2, XP_005249832.1, XP_006715801.1, XP_006715802.1
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
protein associated with LIN7 2, MAGUK p55 family member
- Symbol
- PALS2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:24,572,936-24,694,193
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene.
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001).[supplied by OMIM]
Excerpted from Wikipedia’s “PALS2” article, available under the CC BY-SA 4.0 licence.