PAM16

Also known as MAGMAS, TIM16, TIMM16, CGI-136, SMDMDM, presequence translocase-associated motor 16 homolog (S. cerevisiae), presequence translocase associated motor 16 homolog, presequence translocase associated motor 16

Mitochondrial import inner membrane translocase subunit TIM16 also known as presequence translocated-associated motor subunit PAM16, mitochondria-associated granulocyte macrophage CSF-signaling molecule, or presequence translocated-associated motor subunit PAM16 is a protein that in humans is encoded by the PAM16 gene.

Gene data

PAM16

Name: presequence translocase associated motor 16
Type: protein-coding
Position: 4,330,378–4,355,607 (−)
Aliases: CGI-136, MAGMAS, SMDMDM, TIM16, TIMM16
Ensembl: ENSG00000217930
RefSeq RNA: NM_016069.11
RefSeq protein: NP_057153.8

This gene encodes a mitochondrial protein involved in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. This protein also plays a role in the import of nuclear-encoded mitochondrial proteins into the mitochondrial matrix and may be important in reactive oxygen species (ROS) homeostasis. Mutations in this gene cause Megarbane-Dagher-Melike type spondylometaphyseal dysplasia, an early lethal skeletal dysplasia characterized by short stature, developmental delay and other skeletal abnormalities. [provided by RefSeq, May 2017].

Gene Ontology

Biological process

ossification intracellular protein transport protein import into mitochondrial matrix protein import into mitochondrial matrix protein import into mitochondrial matrix negative regulation of ATP-dependent activity

Molecular function

protein binding

Cellular component

PAM complex, Tim23 associated import motor PAM complex, Tim23 associated import motor PAM complex, Tim23 associated import motor PAM complex, Tim23 associated import motor mitochondrion mitochondrion mitochondrial inner membrane mitochondrial inner membrane

Pathways

Mitochondrial protein import Protein localization

via MyGene.info

Gene · Ensembl

presequence translocase associated motor 16

Symbol: PAM16
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:4,330,378-4,355,607
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 41100
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/51025
chromosome: human chromosome 16
genomic start: 4381550
genomic end: 4405608
cytogenetic location: 16p13.3

Sources (4)

via Wikidata · CC0

~2 min read

Encyclopedic overview

6 sections

Contents

Structure
Function
Clinical Significance
Interactions
References
Further reading

== Structure == The PAM16 gene is located on the p arm of chromosome 16 at position 13.3 and it spans 11,150 base pairs. The PAM16 gene produces a 15.1 kDa protein composed of 137 amino acids. The structure has been found to contain a 21-residue mitochondrial targeting leader sequence.

Excerpted from Wikipedia’s “PAM16” article, available under the CC BY-SA 4.0 licence.

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