PANK1
Sign in to saveAlso known as PANK, pantothenate kinase 1
Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.
Gene data
PANK1- Name
- pantothenate kinase 1
- Type
- protein-coding
- Position
- 89,579,497–89,645,263 (−)
- Aliases
- PANK
- Ensembl
- ENSG00000152782
- RefSeq RNA
- NM_138316.4, NM_148977.3, NM_148978.3, XM_017016333.3, XM_017016334.2
- RefSeq protein
- NP_612189.2, NP_683878.2, NP_683879.1, XP_016871822.1, XP_016871823.1
This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
pantothenate kinase 1
- Symbol
- PANK1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:89,579,497-89,645,263
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PANK1 PDB 2i7n.png
Show 8 more facts
- HomoloGene ID
- 56979
- genomic start
- 91342745
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/53354
- genomic end
- 89645242
- chromosome
- human chromosome 10
- cytogenetic location
- 10q23.31
- expressed in
- rectum
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.
This gene encodes a protein belonging to the pantothenate kinase family, which in mammals is made of up PANK1, PANK2, PANK3, and PANK4. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.
Excerpted from Wikipedia’s “PANK1” article, available under the CC BY-SA 4.0 licence.