Image by Nolde on Pixabay · Pixabay License
Pappalysin 1
Sign in to saveAlso known as IGFBP-4ase, aspecific BCL2 ARE-binding protein 2, IGF-dependent IGFBP-4 protease, Pregnancy-associated plasma protein A, PAPP-A, Insulin-like growth factor-dependent IGF-binding protein 4 protease, pregnacy-associated plasma protein A, differentially placenta 1 expressed protein
mammalian protein found in Homo sapiens
Protein · UniProt
Pappalysin-1
- Gene
- PAPPA
- Organism
- Homo sapiens (Human)
- Length
- 1,627 aa
- Molecular mass
- 180,973 Da
- Evidence
- 1: Evidence at protein level
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF
3D-structureDirect protein sequencingDisulfide bondGlycoproteinHydrolaseMetal-bindingMetalloproteaseProtease
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
73 papers- CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis.Andrologia · 2021
- The Stanniocalcin-PAPP-A-IGFBP-IGF Axis.The Journal of clinical endocrinology and metabolism · 2023
- Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors.Cellular and molecular gastroenterology and hepatology · 2020
- Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer.EMBO molecular medicine · 2016
- EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1.Genes & cancer · 2017
via PubMed
Clinical Trials
4 registered- COMPLETEDAnalysis of Pregnancy-Associated Plasma Protein-A and Interleukin-6 Gene Polymorphisms in Patients With PeriodontitisMarmara University · NCT06540755
- NAUNKNOWNDown Syndrome - Comparison of Screening Methods in the 1st and 2nd TrimestersEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · NCT00006445
- COMPLETEDSerum Sample Collection to Determine Analytical Performance Characteristics of the ADVIA Centaur PAPPA and BhCG AssaysAxis Shield Diagnostics Ltd · NCT03629795
- UNKNOWNEvaluation of Pregnancy Associated Plasma Protein A (PAPPA) as a Biomarker in Breast Cancer.Assiut University · NCT06174571