PATZ1

Also known as MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23, POZ/BTB and AT hook containing zinc finger 1

POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.

In the Vinony graph

Within Vinony's link graph, PATZ1 is referenced by 4 other articles, and connects out to Q180686, human chromosome 22 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 22.

Its subject is documented across 6 Wikipedia language editions.

Gene data

PATZ1

Name: POZ/BTB and AT hook containing zinc finger 1
Type: protein-coding
Position: 31,325,804–31,346,605 (−)
Aliases: MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23
Ensembl: ENSG00000100105
RefSeq RNA: NM_014323.3, NM_032050.2, NM_032051.2, NM_032052.2
RefSeq protein: NP_055138.2, NP_114439.1, NP_114440.1, NP_114441.1

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008].