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GeneQ18047761· pop 6· linked from 5 articles

PCGF1

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Also known as 2010002K04Rik, NSPC1, RNF3A-2, RNF68, polycomb group ring finger 1

Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68 is a RING finger domain protein that in humans is encoded by the PCGF1 gene.

Gene data

PCGF1
Name
polycomb group ring finger 1
Type
protein-coding
Position
74,505,041–74,508,361 (−)
Aliases
2010002K04Rik, NSPC1, RNF3A-2, RNF68
Ensembl
ENSG00000115289
RefSeq RNA
NM_032673.3, XM_054344227.1
RefSeq protein
NP_116062.2, XP_054200202.1

PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008].

Gene Ontology

Pathways

Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)FBXL10 enhancement of MAP-ERK signaling in diffuse large B-cell lymphoma

via MyGene.info

Gene · Ensembl

polycomb group ring finger 1

Symbol
PCGF1
Biotype
Protein coding
Organism
Homo sapiens
Location
2:74,505,041-74,508,361
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
13090
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/84759
genomic end
74507695
genomic start
74732170
chromosome
human chromosome 2
cytogenetic location
2p13.1
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections
Contents
  • References
  • Further reading

Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68 is a RING finger domain protein that in humans is encoded by the PCGF1 gene.

PCGF1 is a component defining the non-canonical polycomb repressive complex 1.1 (ncPRC1) interacting with RING1A/B, RYBP, BCOR and KDM2B. PCGF1-BCOR assembles via the ubiquitin-like RAWUL domain of PCGF1 and is recruited on the chromatin at KDM2B sites. Within the PRC1-like complex, PCGF1 regulates RING1B ubiquitin ligase activity that catalyzes the ubiquitination of Lys119 on histone H2A, which then leads to recruitment of PRC2 and H3K27me3 to effectively initiate a polycomb domain and mediate gene repression.

Excerpted from Wikipedia’s “PCGF1” article, available under the CC BY-SA 4.0 licence.

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