PDCD6IP
Sign in to saveAlso known as AIP1, ALIX, DRIP4, HP95, programmed cell death 6 interacting protein
Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.
Gene data
PDCD6IP- Name
- programmed cell death 6 interacting protein
- Type
- protein-coding
- Position
- 33,798,318–33,869,707 (+)
- Aliases
- AIP1, ALIX, DRIP4, HP95, MCPH29
- Ensembl
- ENSG00000170248
- RefSeq RNA
- NM_001162429.3, NM_001256192.2, NM_013374.6, NR_027867.1, XM_011533252.2
- RefSeq protein
- NP_001155901.1, NP_001243121.1, NP_037506.2, XP_011531554.1, XP_047302998.1
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
programmed cell death 6 interacting protein
- Symbol
- PDCD6IP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:33,798,318-33,869,707
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.
This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.
Excerpted from Wikipedia’s “PDCD6IP” article, available under the CC BY-SA 4.0 licence.