PDE10A

Also known as HSPDE10A, PDE10A19, ADSD2, IOLOD, phosphodiesterase 10A, LINC00473

'''cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' is an enzyme that in humans is encoded by the PDE10A'' gene.

In the Vinony graph

Within Vinony's link graph, PDE10A is referenced by 12 other articles, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.

Vinony files it under EC 3.1.4 and Genes on human chromosome 6.

Its subject is documented across 5 Wikipedia language editions.

Gene data

PDE10A

Name: phosphodiesterase 10A
Type: protein-coding
Position: 165,327,287–165,988,117 (−)
Aliases: ADSD2, HSPDE10A, IOLOD, PDE10A19
Ensembl: ENSG00000112541
RefSeq RNA: NM_001130690.3, NM_001385079.1, NM_001445283.1, NM_001445284.1, NM_001445285.1
RefSeq protein: NP_001124162.1, NP_001372008.1, NP_001432212.1, NP_001432213.1, NP_001432214.1

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011].

Gene Ontology

Biological process

cAMP catabolic process signal transduction negative regulation of receptor guanylyl cyclase signaling pathway cGMP catabolic process negative regulation of cAMP/PKA signal transduction

Molecular function

cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity

Cellular component

cytosol cytosol synapse glutamatergic synapse

Pathways

Purine metabolism - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Morphine addiction - Homo sapiens (human)Hemostasis Signal Transduction Signaling by GPCR GPCR downstream signalling Nitric oxide stimulates guanylate cyclase Platelet homeostasis cGMP effects

via MyGene.info

Gene · Ensembl

phosphodiesterase 10A

Symbol: PDE10A
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:165,327,287-165,988,117
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein PDE10A PDB 2o8h.png

Show 9 more facts

HomoloGene ID: 4852
found in taxon: Homo sapiens
genetic association: conduct disorder
exact match: identifiers.org/ncbigene/10846
genomic start: 165740776
chromosome: human chromosome 6
genomic end: 165988117
cytogenetic location: 6q27
expressed in: caudate nucleus

Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Inhibitors
Research
References
Further reading

'''cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' is an enzyme that in humans is encoded by the PDE10A'' gene.

Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.

Excerpted from Wikipedia’s “PDE10A” article, available under the CC BY-SA 4.0 licence.