PDE10A
Sign in to saveAlso known as HSPDE10A, PDE10A19, ADSD2, IOLOD, phosphodiesterase 10A, LINC00473
'''cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' is an enzyme that in humans is encoded by the PDE10A'' gene.
Gene data
PDE10A- Name
- phosphodiesterase 10A
- Type
- protein-coding
- Aliases
- ADSD2, HSPDE10A, IOLOD, PDE10A19
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011].
via MyGene.info
Wikidata facts
- Image
- Protein PDE10A PDB 2o8h.png
Show 5 more facts
- HomoloGene ID
- 4852
- exact match
- identifiers.org/ncbigene/10846
- genomic start
- 165740776
- genomic end
- 165988117
- cytogenetic location
- 6q27
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Article
4 sectionsContents
- Inhibitors
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'''cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' is an enzyme that in humans is encoded by the PDE10A'' gene.
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.