Pentraxin 3
Sign in to saveAlso known as tumor necrosis factor alpha-induced protein 5, pentraxin-related protein PTX3, Pentaxin-related protein PTX3, tumor necrosis factor-inducible gene 14 protein, tumor necrosis factor-inducible protein TSG-14, PTX3, long pentraxin 3, TNF alpha-induced protein 5
Pentraxin-related protein PTX3 also known as TNF-inducible gene 14 protein (TSG-14) is a protein that in humans is encoded by the PTX3 gene.
Protein · UniProt
Pentraxin-related protein PTX3
- Gene
- PTX3
- Organism
- Homo sapiens (Human)
- Length
- 381 aa
- Molecular mass
- 41,976 Da
- Evidence
- 1: Evidence at protein level
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
23 registered- COMPLETEDThe Role of Pentraxin 3 and Cathepsin B Levels in Preeclamptic PregnancySanliurfa Mehmet Akif Inan Education and Research Hospital · NCT05924061
- COMPLETEDPreeclamptic Patients and Pentraxin 3 & Lipoprotein-associated Phospholipase A2Kanuni Sultan Suleyman Training and Research Hospital · NCT04239352
- UNKNOWNEvaluation of pentraxin3 as a Marker for Ventilator Associated PneumoniaAssiut University · NCT04111224
- COMPLETEDEstimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal DiseaseCairo University · NCT03128502
- COMPLETEDPentraxin-3 in Hysterectomy PatientsMuğla Sıtkı Koçman University · NCT04366375
- COMPLETEDEffect of LDL-apheresis on PTX3 Plasma Levels in Hypercholesterolemic PatientsUniversita di Verona · NCT01678521
Wikidata facts
- Instance of
- protein
Show 3 more facts
- biological process
- innate immune response
- cell component
- extracellular matrix
- found in taxon
- Homo sapiens
via Wikidata · CC0
~4 min read
Encyclopedic overview
5 sectionsContents
- Structure
- PTX3 in blood
- Pathogen versus apoptotic self recognition
- References
- Further reading
Pentraxin-related protein PTX3 also known as TNF-inducible gene 14 protein (TSG-14) is a protein that in humans is encoded by the PTX3 gene.
Pentraxin 3 (ptx3) is a member of the pentraxin superfamily. This super family characterized by cyclic multimeric structure. PTX3 is rapidly produced and released by several cell types, in particular by mononuclear phagocytes, dendritic cells (DCs), fibroblasts and endothelial cells in response to primary inflammatory signals [e.g., toll-like receptor (TLR) engagement, TNFα, IL-1β]. PTX3 binds with high affinity to the complement component C1q, the extracellular matrix component TNFα induced protein 6 (TNFAIP6; also called TNF-stimulated gene 6, TSG-6) and selected microorganisms, including Aspergillus fumigatus and Pseudomonas aeruginosa.
Excerpted from Wikipedia’s “Pentraxin 3” article, available under the CC BY-SA 4.0 licence.