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phaeohyphomycosis

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Also known as Infection by dematiacious fungi, Infection by dematiacious fungi [Phaehyphomycosis], phaehyphomycosis, pheohyphomycosis

Phaeohyphomycosis is a diverse group of fungal infections, caused by dematiaceous fungi whose morphologic characteristics in tissue include hyphae, yeast-like cells, or a combination of these. It can be associated with an array of melanistic filamentous fungi including Alternaria species, Exophiala jeanselmei, and Rhinocladiella mackenziei.

Research

1,259 papers

via PubMed

~9 min read

Encyclopedic overview

10 sections
Contents
  • Clinical signs of phaeohyphomycosis
  • Wildlife
  • Invertebrates
  • Cold-blooded vertebrates
  • Warm-blooded vertebrates
  • Humans
  • Treatment
  • Research projects and implications
  • See also
  • References

Phaeohyphomycosis is a diverse group of fungal infections, caused by dematiaceous fungi whose morphologic characteristics in tissue include hyphae, yeast-like cells, or a combination of these. It can be associated with an array of melanistic filamentous fungi including Alternaria species, Exophiala jeanselmei, and Rhinocladiella mackenziei.

The term "phaeohyphomycosis" was introduced to determine infections caused by dematiaceous (pigmented) filamentous fungi which contain melanin in their cell walls. Phaeohyphomycosis is an uncommon infection, but the number of cases reported has been increasing in recent years. Fungal melanin is thought to be a virulence factor. The outcome of antifungal treatment is poor, and mortality is almost 80%. Phaeohyphomycosis has been attributed to more than 100 species and 60 genera of fungi over the past several decades. The pathogens are considered opportunistic. Almost all cases of widely disseminated infection have occurred in immunosuppressed people.

Excerpted from Wikipedia’s “phaeohyphomycosis” article, available under the CC BY-SA 4.0 licence.

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