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GeneQ18041804· pop 6· linked from 2 articles

PIDD1

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Also known as LRDD, PIDD, p53-induced death domain protein 1

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.

Gene data

PIDD1
Name
p53-induced death domain protein 1
Type
protein-coding
Position
798,938–809,753 (−)
Aliases
LRDD, MRT75, PIDD, altPIDD1
Ensembl
ENSG00000177595
RefSeq RNA
NM_018494.3, NM_145886.4, NM_145887.4, XM_005253005.6, XM_005253006.6
RefSeq protein
NP_665893.2, NP_665894.2, XP_005253062.1, XP_005253063.1, XP_011518511.1

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010].

Gene Ontology

Pathways

NF-kappa B signaling pathway - Homo sapiens (human)p53 signaling pathway - Homo sapiens (human)Apoptosis - Homo sapiens (human)Generic Transcription PathwayTranscriptional Regulation by TP53TP53 Regulates Transcription of Cell Death GenesTP53 Regulates Transcription of Caspase Activators and CaspasesRNA Polymerase II TranscriptionGene expression (Transcription)miRNA regulation of DNA damage response

via MyGene.info

Gene · Ensembl

p53-induced death domain protein 1

Symbol
PIDD1
Biotype
Protein coding
Organism
Homo sapiens
Location
11:798,938-809,753
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~22 min read

Encyclopedic overview

18 sections
Contents
  • The identification of PIDD1
  • Death domain
  • Differential display analysis
  • Structure of PIDD1
  • Death fold
  • Parts and cleavages
  • Role of chaperones
  • Multiprotein Complexes Containing PIDD1
  • PIDDosome
  • Caps-2-PIDDosome
  • PCNA-PIDDosome
  • Relation of PIDD1 to centrosomes
  • Function
  • Caspase-2-PIDDosome
  • PIDD1 and Cancer
  • Recent Interests on PIDD1
  • References
  • Further reading

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.

The leucine-rich repeat (LRR), first identified by Patthy, is a domain involved in protein-protein interactions and is present in numerous proteins that serve a variety of cellular roles. Leucine-rich repeats (LRR) proteins in eukaryotic cells are found in the nucleus, cytoplasm, extracellular matrix and plasma membrane.

Excerpted from Wikipedia’s “PIDD1” article, available under the CC BY-SA 4.0 licence.

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