PNPLA3
Sign in to saveAlso known as ADPN, C22orf20, iPLA(2)epsilon, patatin like phospholipase domain containing 3
Patatin-like phospholipase domain-containing protein 3 (PNPLA3), also known as adiponutrin (ADPN), acylglycerol O-acyltransferase or calcium-independent phospholipase A2-epsilon (iPLA2-epsilon) is an enzyme that in humans is encoded by the PNPLA3 gene.
Gene data
PNPLA3- Name
- patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase
- Type
- protein-coding
- Position
- 43,923,761–43,964,488 (+)
- Aliases
- ADPN, C22orf20, iPLA(2)epsilon
- Ensembl
- ENSG00000100344
- RefSeq RNA
- NM_025225.3
- RefSeq protein
- NP_079501.2
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase
- Symbol
- PNPLA3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:43,923,761-43,964,488
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 11883
- genetic association
- fatty liver disease
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/80339
- genomic end
- 44360368
- genomic start
- 43923792
- chromosome
- human chromosome 22
- cytogenetic location
- 22q13.31
- expressed in
- middle temporal gyrus
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Genomics
- Biochemistry
- Clinical relevance
- References
- Further reading
Patatin-like phospholipase domain-containing protein 3 (PNPLA3), also known as adiponutrin (ADPN), acylglycerol O-acyltransferase or calcium-independent phospholipase A2-epsilon (iPLA2-epsilon) is an enzyme that in humans is encoded by the PNPLA3 gene.
== Function ==
Excerpted from Wikipedia’s “PNPLA3” article, available under the CC BY-SA 4.0 licence.