POLR2F

Also known as HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15, polymerase (RNA) II subunit F

DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene.

Gene data

POLR2F

Name: RNA polymerase II, I and III subunit F
Type: protein-coding
Position: 37,952,607–38,041,915 (+)
Aliases: HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15
Ensembl: ENSG00000100142
RefSeq RNA: NM_001301129.2, NM_001301130.2, NM_001301131.2, NM_001363825.1, NM_021974.5
RefSeq protein: NP_001288058.1, NP_001288059.1, NP_001288060.1, NP_001350754.1, NP_068809.1

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

Gene Ontology

Biological process

DNA-templated transcription transcription by RNA polymerase I transcription initiation at RNA polymerase I promoter transcription elongation by RNA polymerase I termination of RNA polymerase I transcription transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter

Molecular function

DNA binding DNA-directed RNA polymerase activity DNA-directed RNA polymerase activity

Cellular component

fibrillar center nucleus nucleus nucleus nucleoplasm nucleoplasm RNA polymerase II, core complex RNA polymerase II, core complex

Pathways

RNA polymerase - Homo sapiens (human)Cytosolic DNA-sensing pathway - Homo sapiens (human)Huntington disease - Homo sapiens (human)Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Signaling by FGFR in disease Developmental Biology Telomere Maintenance Signal Transduction HIV Life Cycle

via MyGene.info

Gene · Ensembl

RNA polymerase II, I and III subunit F

Symbol: POLR2F
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:37,952,607-38,041,932
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein POLR2F PDB 1qkl.png

Show 5 more facts

HomoloGene ID: 7178
exact match: identifiers.org/ncbigene/5435
genomic end: 38437922
genomic start: 38348614
cytogenetic location: 22q13.1

Sources (4)

via Wikidata · CC0

Article · Русский

Субъединица RPABC2 ДНК-управляемой РНК-полимеразы I, II и III — белок, кодируемый у человека, геном POLR2F . Этот ген кодирует шестую по величине субъединицу РНК-полимеразы II, полимеразы, ответственной за синтез мессенджера РНК у эукариот, в котором также участвуют две других ДНК-управляемых РНК-полимеразы. У дрожжей, эта полимеразная субъединица, в комбинации по меньшей мере с двумя другими субъединицами, образует структуру, которая стабилизирует транскрипцию полимеразы в матрице ДНК.

Abstract from DBpedia / Wikipedia · CC BY-SA