PPP1R13B
Sign in to saveAlso known as ASPP1, p53BP2-like, p85, protein phosphatase 1 regulatory subunit 13B
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.
In the Vinony graph
Within Vinony's link graph, PPP1R13B is referenced by 4 other articles, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Its subject is documented across 5 Wikipedia language editions.
Gene data
PPP1R13B- Name
- protein phosphatase 1 regulatory subunit 13B
- Type
- protein-coding
- Position
- 103,733,177–103,847,616 (−)
- Aliases
- ASPP1, p53BP2-like, p85
- Ensembl
- ENSG00000088808
- RefSeq RNA
- NM_015316.3, XM_005267487.6, XM_011536593.4, XM_017021116.2, XM_017021117.2
- RefSeq protein
- NP_056131.2, XP_005267544.1, XP_011534895.1, XP_016876605.1, XP_016876606.1
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
protein phosphatase 1 regulatory subunit 13B
- Symbol
- PPP1R13B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:103,733,177-103,847,616
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 9090
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23368
- genomic end
- 103847575
- genomic start
- 103733195
- chromosome
- human chromosome 14
- cytogenetic location
- 14q32.33
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
Excerpted from Wikipedia’s “PPP1R13B” article, available under the CC BY-SA 4.0 licence.