PPP1R13B
Sign in to saveAlso known as ASPP1, p53BP2-like, p85, protein phosphatase 1 regulatory subunit 13B
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.
Gene data
PPP1R13B- Name
- protein phosphatase 1 regulatory subunit 13B
- Type
- protein-coding
- Position
- 103,733,177–103,847,616 (−)
- Aliases
- ASPP1, p53BP2-like, p85
- Ensembl
- ENSG00000088808
- RefSeq RNA
- NM_015316.3, XM_005267487.6, XM_011536593.4, XM_017021116.2, XM_017021117.2
- RefSeq protein
- NP_056131.2, XP_005267544.1, XP_011534895.1, XP_016876605.1, XP_016876606.1
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
protein phosphatase 1 regulatory subunit 13B
- Symbol
- PPP1R13B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:103,733,177-103,847,616
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 9090
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23368
- genomic end
- 103847575
- genomic start
- 103733195
- chromosome
- human chromosome 14
- cytogenetic location
- 14q32.33
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
Excerpted from Wikipedia’s “PPP1R13B” article, available under the CC BY-SA 4.0 licence.