PPP1R14A
Sign in to saveAlso known as CPI-17, CPI17, PPP1INL, protein phosphatase 1 regulatory inhibitor subunit 14A
Protein phosphatase 1 regulatory subunit 14A also known as CPI-17 (C-kinase potentiated Protein phosphatase-1 Inhibitor Mr = 17 kDa) is a protein that in humans is encoded by the PPP1R14A gene.
Gene data
PPP1R14A- Name
- protein phosphatase 1 regulatory inhibitor subunit 14A
- Type
- protein-coding
- Position
- 38,250,856–38,256,615 (−)
- Aliases
- CPI-17, CPI17, PPP1INL
- Ensembl
- ENSG00000167641
- RefSeq RNA
- NM_001243947.2, NM_033256.3
- RefSeq protein
- NP_001230876.1, NP_150281.1
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology
Molecular function
Cellular component
Pathways
via MyGene.info
~2 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Protein phosphatase 1 regulatory subunit 14A also known as CPI-17 (C-kinase potentiated Protein phosphatase-1 Inhibitor Mr = 17 kDa) is a protein that in humans is encoded by the PPP1R14A gene.
== Function == CPI-17 is a phosphorylation-dependent inhibitor protein of smooth muscle myosin phosphatase, discovered in pig aortic homogenates. Phosphorylation of the Thr-38 residue converts the protein into a potent inhibitor for myosin phosphatase. A single phosphorylation of CPI-17 at Thr-38 triggers a global conformational change that causes re-alignment of four helices. Multiple kinases are identified to phosphorylate CPI-17, such as PKC, ROCK, PKN, ZIPK, ILK, and PAK. Agonist stimulation of smooth muscle enhances CPI-17 phosphorylation mainly through PKC and ROCK. Myosin phosphatase inhibition increases myosin phosphorylation and smooth muscle contraction in the absence of increased intracellular Ca2+ concentration. This phenomenon is known as Ca2+ sensitization, which occurs in response to agonist stimulation of smooth muscle. In Purkinje neuron, CPI-17 is involved in long-term synaptic depression.
Excerpted from Wikipedia’s “PPP1R14A” article, available under the CC BY-SA 4.0 licence.