PROX1
Sign in to saveAlso known as prospero homeobox 1
Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.
Gene data
PROX1- Name
- prospero homeobox 1
- Type
- protein-coding
- Position
- 213,982,711–214,041,510 (+)
- Ensembl
- ENSG00000117707
- RefSeq RNA
- NM_001270616.2, NM_002763.5, XM_005273194.3, XM_005273195.5, XM_011509771.2
- RefSeq protein
- NP_001257545.1, NP_002754.2, XP_005273251.1, XP_005273252.1, XP_011508073.1
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
prospero homeobox 1
- Symbol
- PROX1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:213,982,711-214,041,510
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2069
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5629
- genomic end
- 214041510
- genomic start
- 214156524
- chromosome
- human chromosome 1
- cytogenetic location
- 1q32.3
- Commons category
- PROX1
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
7 sectionsContents
- Interactions
- Production
- Clinical significance
- Homologous gene
- References
- Further reading
- External links
Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.
==Interactions== PROX1 has been shown to interact with EP300.
Excerpted from Wikipedia’s “PROX1” article, available under the CC BY-SA 4.0 licence.